منابع مشابه
Introduction to the Proceedings of the 12Th Germinal Centre Conference — Thirty Years of Germinal Centre Conferences
"In Vivo Veritas": Under this motto, the twelfth socalled Germinal Centre Conference was held in Graz, Austria, July 1 to 5, 1996, with Prof. Konrad Schauenstein chairing the organizing committee, with the assistance of Dr. Richard Boyd (Australia). Despite the progress that is being made using in vitro models, some immunologists believe that "the proof of the pudding is in the eating", that is...
متن کاملTriple check for antigen specificity of B cells during germinal centre reactions.
Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differe...
متن کاملUvA - DARE ( Digital Academic Repository ) Triple check for antigen specificity of B cells during germinal centre reactions
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متن کاملThe Ectopic Germinal Centre Response in Autoimmune Disease and Cancer
1.1 The B-cell response in autoimmune disease1 The pathological effects of autoimmune diseases on the target tissues can be mediated by autoantibodies, cell-mediated immune responses, or both. It is increasingly evident that some autoimmune diseases previously thought to be essentially T-cell-mediated also have a B-cell component, which may involve direct effects of autoantibody secreted by pla...
متن کاملA mathematical model for germinal centre kinetics and affinity maturation.
We present a mathematical model which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immune response and on affinity maturation observed during the reaction. We show that antigen masking by antibodies which are produced by emerging plasma cells can drive affinity maturation and provide a feedback mechanism by which the reaction is stable against variatio...
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ژورنال
عنوان ژورنال: Current Opinion in Systems Biology
سال: 2019
ISSN: 2452-3100
DOI: 10.1016/j.coisb.2019.10.004